Baohuoside I Inhibits the Proliferation of Pancreatic Cancer Cells via mTOR/S6K1-Caspases/Bcl2/Bax Apoptotic Signaling
Identifieur interne : 000A11 ( Main/Exploration ); précédent : 000A10; suivant : 000A12Baohuoside I Inhibits the Proliferation of Pancreatic Cancer Cells via mTOR/S6K1-Caspases/Bcl2/Bax Apoptotic Signaling
Auteurs : Fubiao Ni [République populaire de Chine] ; Hengjie Tang [République populaire de Chine] ; Cheng Wang [République populaire de Chine] ; Hewei Zhang [République populaire de Chine] ; Chenlei Zheng [République populaire de Chine] ; Ning Zhang [République populaire de Chine] ; Bicheng Chen [République populaire de Chine] ; Linxiao Sun [République populaire de Chine]Source :
- Cancer Management and Research [ 1179-1322 ] ; 2019.
Abstract
Although the incidence of pancreatic cancer has increased markedly, the 5-year survival rate for this disease is considerably low compared with other types of cancer. Moreover, the mortality rate of pancreatic cancer is similar to its incidence rate. Current therapeutic agents exhibit a lack of specificity for pancreatic cancer. Baohuoside I is traditionally used to treat orgasmic disorder and inflammation. However, its role in pancreatic cancer is unknown.
To explore the effects of Baohuoside I on pancreatic cancer and to study the potential-related molecular mechanism.
In the present study, the antineoplastic effect of Baohuoside I was investigated with regard to pancreatic cancer via colony formation, transwell and migration assay. The energy metabolism changes of pancreatic cancer were tested by flow cytometry analysis and oxidative phosphorylation and glycolysis assay. The target signaling members were analyzed by Western blot.
Baohuoside I inhibited the cell growth of pancreatic cancer cells. In addition, it affected intracellular energy metabolism to induce cancer cell apoptosis via the mTOR/S6K1 and the caspase/Bcl2/Bax signaling pathways.
The present data provide further insight into the development of novel drugs against pancreatic cancer.
Url:
DOI: 10.2147/CMAR.S228926
PubMed: 31908533
PubMed Central: 6927568
Affiliations:
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strict</wicri:regionArea></affiliation></author><author><name sortKey="Sun, Linxiao" sort="Sun, Linxiao" uniqKey="Sun L" first="Linxiao" last="Sun">Linxiao Sun</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, Zhejiang Provincial Top Key Discipline in Surgery, First Affiliated Hospital of Wenzhou Medical University</institution>,<addr-line>Wenzhou</addr-line>,<addr-line>Zhejiang</addr-line><addr-line>325000</addr-line>,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31908533</idno><idno type="pmc">6927568</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927568</idno><idno type="RBID">PMC:6927568</idno><idno 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Signaling</title><author><name sortKey="Ni, Fubiao" sort="Ni, Fubiao" uniqKey="Ni F" first="Fubiao" last="Ni">Fubiao Ni</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, Zhejiang Provincial Top Key Discipline in Surgery, First Affiliated Hospital of Wenzhou Medical University</institution>,<addr-line>Wenzhou</addr-line>,<addr-line>Zhejiang</addr-line><addr-line>325000</addr-line>,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tang, Hengjie" sort="Tang, Hengjie" uniqKey="Tang H" first="Hengjie" last="Tang">Hengjie Tang</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, Zhejiang Provincial Top Key Discipline in Surgery, First Affiliated Hospital of Wenzhou Medical University</institution>,<addr-line>Wenzhou</addr-line>,<addr-line>Zhejiang</addr-line><addr-line>325000</addr-line>,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Cheng" sort="Wang, Cheng" uniqKey="Wang C" first="Cheng" last="Wang">Cheng Wang</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, Zhejiang Provincial Top Key Discipline in Surgery, First Affiliated Hospital of Wenzhou Medical University</institution>,<addr-line>Wenzhou</addr-line>,<addr-line>Zhejiang</addr-line><addr-line>325000</addr-line>,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Hewei" sort="Zhang, Hewei" uniqKey="Zhang H" first="Hewei" last="Zhang">Hewei Zhang</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, Zhejiang Provincial Top Key Discipline in Surgery, First Affiliated Hospital of Wenzhou Medical University</institution>,<addr-line>Wenzhou</addr-line>,<addr-line>Zhejiang</addr-line><addr-line>325000</addr-line>,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zheng, Chenlei" sort="Zheng, Chenlei" uniqKey="Zheng C" first="Chenlei" last="Zheng">Chenlei Zheng</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, Zhejiang Provincial Top Key Discipline in Surgery, First Affiliated Hospital of Wenzhou Medical University</institution>,<addr-line>Wenzhou</addr-line>,<addr-line>Zhejiang</addr-line><addr-line>325000</addr-line>,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Ning" sort="Zhang, Ning" uniqKey="Zhang N" first="Ning" last="Zhang">Ning Zhang</name><affiliation wicri:level="1"><nlm:aff id="AFF0002"><institution>First School of Clinical Medicine, Wenzhou Medical University</institution>,<addr-line>Wenzhou</addr-line>,<addr-line>Zhejiang</addr-line><addr-line>325000</addr-line>,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Bicheng" sort="Chen, Bicheng" uniqKey="Chen B" first="Bicheng" last="Chen">Bicheng Chen</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, Zhejiang Provincial Top Key Discipline in Surgery, First Affiliated Hospital of Wenzhou Medical University</institution>,<addr-line>Wenzhou</addr-line>,<addr-line>Zhejiang</addr-line><addr-line>325000</addr-line>,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sun, Linxiao" sort="Sun, Linxiao" uniqKey="Sun L" first="Linxiao" last="Sun">Linxiao Sun</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, Zhejiang Provincial Top Key Discipline in Surgery, First Affiliated Hospital of Wenzhou Medical University</institution>,<addr-line>Wenzhou</addr-line>,<addr-line>Zhejiang</addr-line><addr-line>325000</addr-line>,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Cancer Management and Research</title><idno type="eISSN">1179-1322</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S2001"><title>Background</title><p>Although the incidence of pancreatic cancer has increased markedly, the 5-year survival rate for this disease is considerably low compared with other types of cancer. Moreover, the mortality rate of pancreatic cancer is similar to its incidence rate. Current therapeutic agents exhibit a lack of specificity for pancreatic cancer. Baohuoside I is traditionally used to treat orgasmic disorder and inflammation. However, its role in pancreatic cancer is unknown.</p></sec><sec id="S2002"><title>Objective</title><p>To explore the effects of Baohuoside I on pancreatic cancer and to study the potential-related molecular mechanism.</p></sec><sec id="S2003"><title>Materials and methods</title><p>In the present study, the antineoplastic effect of Baohuoside I was investigated with regard to pancreatic cancer via colony formation, transwell and migration assay. The energy metabolism changes of pancreatic cancer were tested by flow cytometry analysis and oxidative phosphorylation and glycolysis assay. The target signaling members were analyzed by Western blot.</p></sec><sec id="S2004"><title>Results</title><p>Baohuoside I inhibited the cell growth of pancreatic cancer cells. In addition, it affected intracellular energy metabolism to induce cancer cell apoptosis via the mTOR/S6K1 and the caspase/Bcl2/Bax signaling pathways.</p></sec><sec id="S2005"><title>Conclusion</title><p>The present data provide further insight into the development of novel drugs against pancreatic cancer.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Ni, Fubiao" sort="Ni, Fubiao" uniqKey="Ni F" first="Fubiao" last="Ni">Fubiao Ni</name></noRegion><name sortKey="Chen, Bicheng" sort="Chen, Bicheng" uniqKey="Chen B" first="Bicheng" last="Chen">Bicheng Chen</name><name sortKey="Sun, Linxiao" sort="Sun, Linxiao" uniqKey="Sun L" first="Linxiao" last="Sun">Linxiao Sun</name><name sortKey="Tang, Hengjie" sort="Tang, Hengjie" uniqKey="Tang H" first="Hengjie" last="Tang">Hengjie Tang</name><name sortKey="Wang, Cheng" sort="Wang, Cheng" uniqKey="Wang C" first="Cheng" last="Wang">Cheng Wang</name><name sortKey="Zhang, Hewei" sort="Zhang, Hewei" uniqKey="Zhang H" first="Hewei" last="Zhang">Hewei Zhang</name><name sortKey="Zhang, Ning" sort="Zhang, Ning" uniqKey="Zhang N" first="Ning" last="Zhang">Ning Zhang</name><name sortKey="Zheng, Chenlei" sort="Zheng, Chenlei" uniqKey="Zheng C" first="Chenlei" last="Zheng">Chenlei Zheng</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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